Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release
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چکیده
منابع مشابه
Luminal Ca Controls Termination and Refractory Behavior of Ca -Induced Ca Release in Cardiac Myocytes
Despite extensive research, the mechanisms responsible for the graded nature and early termination of Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) in cardiac muscle remain poorly understood. Suggested mechanisms include cytosolic Ca -dependent inactivation/adaptation and luminal Ca -dependent deactivtion of the SR Ca release channels/ryanodine receptors (RyRs). To explore ...
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Ca influx via Ca current (ICa) during the action potential (AP) was determined at 25°C and 35°C in isolated rabbit ventricular myocytes using AP clamp. Contaminating currents through Na and K channels were eliminated by using Naand K-free solutions, respectively. DIDS (0.2 mmol/L) was used to block Ca-activated chloride current (ICl(Ca)). When the sarcoplasmic reticulum (SR) was depleted of Ca ...
متن کاملMeasuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release.
RATIONALE Mitochondrial [Ca(2+)] ([Ca(2+)](mito)) regulates mitochondrial energy production, provides transient Ca(2+) buffering under stress, and can be involved in cell death. Mitochondria are near the sarcoplasmic reticulum (SR) in cardiac myocytes, and evidence for crosstalk exists. However, quantitative measurements of [Ca(2+)](mito) are limited, and spatial [Ca(2+)](mito) gradients have n...
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Tully, Keith and Steven N. Treistman. Distinct intracellular calcium profiles following influx through Nversus L-type calcium channels: role of Ca -induced Ca release. J Neurophysiol 92: 135–143, 2004; 10.1152/jn.01004.2003. Selective activation of neuronal functions by Ca is determined by the kinetic profile of the intracellular calcium ([Ca ]i) signal in addition to its amplitude. Concurrent ...
متن کاملbeta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes.
To elucidate microscopic mechanisms underlying the modulation of cardiac excitation-contraction (EC) coupling by beta-adrenergic receptor (beta-AR) stimulation, we examined local Ca(2+) release function, ie, Ca(2+) spikes at individual transverse tubule-sarcoplasmic reticulum (T-SR) junctions, using confocal microscopy and our recently developed technique for release flux measurement. beta-AR s...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1999
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(99)00038-3